Biomaterials Science, 2nd Edition, An Introduction to Materials in Medicine

Biomaterials Science (2nd Edition) An Introduction to Materials in Medicine covers the broad spectrum of biomaterial compositions including polymers, metals, ceramics, glasses, carbons, natural materials, and composites.

The second edition of this bestselling title provides the most up-to-date comprehensive review of all aspects of biomaterials science by providing a balanced, insightful approach to learning biomaterials. This reference integrates a historical perspective of materials engineering principles with biological interactions of biomaterials. Also provided within are regulatory and ethical issues in addition to future directions of the field, and a state-of-the-art update of medical and biotechnological applications.

All aspects of biomaterials science are thoroughly addressed, from tissue engineering to cochlear prostheses and drug delivery systems. Over 80 contributors from academia, government and industry detail the principles of cell biology, immunology, and pathology. Focus within pertains to the clinical uses of biomaterials as components in implants, devices, and artificial organs. This reference also touches upon their uses in biotechnology as well as the characterization of the physical, chemical, biochemical and surface properties of these materials.

The book is aimed at Biomaterials Engineers, Materials Scientists and Engineers and Clinical Enginners.

INTRODUCTION

BIOMATERIALS HISTORY

PART I: Materials Science & Engineering

Properties of Materials: Introduction

Bulk Properties of Materials

Finite Element Analysis

Surface Properties of Materials

Role of Water in Biomaterials

Classes of Materials Used in Medicine: Introduction

Metals

Polymers

A Brief History of Silicone Biomaterials

Hydrogels

Bioresorbable and Biodegradable Materials

Ceramics, Classes and Class-Ceramics

Natural Materials

Composites

Thin Films, Grafts, Coatings

Medical Fibers and Biotextiles

Biological Functional Materials

Smart Materials

Pyrolytic Carbon for Long-Term Medical Implants

Textured and Porous Materials

Non-fouling Surfaces

PART II: Biology, Biochemistry and Medicine Background Concepts

Introduction

The Role of Absorbed Proteins in Tissue Response to Biomaterials

Calls and Cell Injury

Tissues: The Extracellular Matrix and Call-Biomaterials Interactions

Mechanical Forces on Cells

Host Reactions to Biomaterials and Their Evaluation

Testing Biomaterials

Introduction

Inflammation, Wound Healing and the Foreign Body Response

The Complement Systems

Systemic Toxicity and Hypersensitivity

Blood Coagulation and Blood-Materials Interactions

Tumorigenesis and Biomaterials

Infection

Testing Biomaterials

Introduction

In Vitro Assessment of Tissue Compatibility

In Vivo Assessment of Tissue Compatibility

Testing of Blood-Materials Interactions

Large Animal Models in Cardiac and Vascular

Biomaterials Research and Testing

Microscopy for Biomaterials Science

Degradation of Materials in the Biological Environment

Introduction

Degradation of Materials in the Biological Environment

Degradative Effects of the Biological Environment on Meral and Ceramics

Pathologic Calcification of Biomaterials

Applications of Materials in Medicine, Dentistry and Biology

Introduction

Cardiovascular Medical Devices

Nonthrombogenic Treatments and Strategies

Dental Implantation

Adhesives and Sealants

Ophthalmologic Applications

Intraocular Lens Implants: A Scientific Perspective

Clinical Aspects of Orthopedic Biomaterial

Performance

Drug Delivery Systems

Sutures

Burn Dressings and Skin Substitutes

Bioelectrodes

Biomedical Sensors and Biosensors

Diagnostics and Biomaterials

Artificial Organs and Tissues

Introduction

Implantable Cardiac Assist Devices

Extracorporeal Artificial Organs

Cochlear Implants

Artificial Red Blood Cell Substitutes

Tissue Engineering

Introduction

Overview of Tissue Engineering

Immunoissolation

Synthetic Bioresorbable Polymer Scaffolds

PART III: Practical Aspects of Biomaterials

Implants & Devices - Special Concerns

Introduction

Sterilization of Implants and Devices

Implants and Device Failure

Correlations of Materials Surface Properties with Biological Responses

Implant Retrieval and Evaluation

New Products and Standards

Introduction

Voluntary Consensus Standards

Development and Regulation of Medical Products

Using Biomaterials

Ethical Issues in the Development of New Biomaterials

Legal Aspects of Biomaterials

Perspectives and Possibilities in Biomaterials Science

APPLIANCES